<i>Lactobacillus plantarum</i> AR113 attenuates liver injury in <i>D</i>-Galactose-induced aging mice via the inhibition of oxidative stress and endoplasmic reticulum stress

Probiotics could effectively eliminate excess ROS generated during aging or lipid metabolism disorders, but their mechanism is unclear. The major purpose of this study was to investigate the L. plantarun AR113 alleviating oxidative stress injury in D-galactose induced mice. result showed that pretreatment with significantly relieving H2O2 cytotoxicity HepG2 cells by maintain cell membrane integrity and increasing antioxidant enzyme activities. In mice, attenuate liver damage inflammatory infiltration promoting endogenous GSH synthesis activating Nrf2/Keap1 signaling pathway expression regulated phase Ⅱ detoxification enzymes enzymes. Further analysis shown gavage reduce GRP78 CHOP proteins, promote restoration ER homeostasis, thereby anti-apoptotic pathways. These results were also confirmed H2O2-treated experiments. It indicated inhibit D-galactose-induced through dual inhibition stress. have good application potential anti-aging metabolic disorders.